Duodenal Ascorbate Levels Are Changed in Mice with Altered Iron Metabolism

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.

Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload. Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the ir...

Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out.

Hereditary hemochromatosis is a common iron-loading disorder found in populations of European descent. It has been proposed that mutations causing loss of function of HFE gene result in reduced iron incorporation into immature duodenal crypt cells. These cells then overexpress genes for iron absorption, leading to inappropriate cellular iron balance, a persistent iron deficiency of the duodenal...

People with Parkinson's show altered iron levels in their brains

altered concentrations of copper, zinc, and iron are associated with increased levels of glycated hemoglobin in patients with type 2 diabetes mellitus and their first-degree relatives

background the altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. objectives the aim of the present study was to compare the concentrations of essential trace elements, copper (cu), zinc (zn), and iron (fe) in the serum of patients who have type 2 diabetes mellitus (t2dm) with those of their non-diabetic first-degree relatives (fdr)...

Altered lipoprotein metabolism in transgenic mice

Transgenic mouse lines were produced that expressed low levels of a receptor-binding-defective variant of human apolipoprotein (apo) E, apoE(Argll2, Cys142). In transgenic mice, the human apoE was produced only by the kidney, whereas endogenous mouse apoE was produced mainly by the liver. The plasma concentration of the transgenic protein was about half that of endogenous apoE. The expression o...